氫氣水可以治療牙周病
這是首次將氫氣用在口腔疾病的研究，這一研究的重要性是給我們提供了新的治療疾病類型，但這一疾病的重要性是發病率特別高，大部分人都會在某一階段存在一定的牙齒問題，而牙周病又占比較高的比例。這一疾病不僅適合進行臨床研究，而且適合個人嘗試。氫氣水非常容易獲得實驗使用800-1000ppb濃度之含氫水，存至於鋁製袋中施予受測對象，對這個疾病，可以不需要飲用（但不限制），只需要漱口或含在口中就可以達到治療目的。從個人的體會看，口腔疾病，例如口腔潰瘍，直接漱口效果是非常理想的。希望很快將能看到人體試驗的報告。
本研究論文剛剛發表，目前尚沒有獲得全文，只是根據摘要的理解，可能存在偏差，引用請注意查看全文。
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2011.01801.x/full
活性氧在牙周病的發展過程中發揮重要作用。因為氫氣分子可以作為活性氧清除劑，我們檢測了富氫氣水對大鼠牙周病的治療效果。將縫合線放在大鼠上頜骨臼齒周圍4周誘導牙周病，動物給飲普通水或富氫氣（對牙周病來講，反復用氫氣水漱口，或者用嘴含氫氣更好，不過動物可不會漱口）。結果發現：與正常無牙周病大鼠比較，飲用普通水的牙周病大鼠血清中活性氧隨著時間延長逐漸增加，同時齒槽骨出現中性顆粒細胞浸潤和骨質丟失（大概是牙周病的典型表現）。飲用富氫氣水牙周病大鼠血清中活性氧沒有增加， 4周後齒槽骨8oHdG和硝基酪氨酸表達減少（氧化損傷指標），而且中性顆粒細胞浸潤和骨質丟失也明顯受到保護。而且與炎症有關的信號傳導通路MAPK也受到明顯抑制。
氫水的製備方法可透過1.電解，2.水與礦石反應、3.高壓灌注，選擇任一方法均可備製水中含氫之氫水，任一方法皆可並無特殊性、惟成本與時間之差異。美國、日本、韓國、中國研究中使用之氫水，均因其實驗設計使用三種方式產生氫水，水中含氫氣即為氫水，檢測方法須應用溶氫檢測儀檢測之、只要水中含氫氣即為醫學研究所定義之氫水。
結論：氫氣可以通過降低齒齦周圍炎症氧化損傷預防牙周病
Hydrogen-rich water attenuates experimental periodontitis in a rat model
Kenta Kasuyama, Takaaki Tomofuji, Daisuke Ekuni, Naofumi Tamaki, Tetsuji Azuma, Koichiro Irie, Yasumasa Endo， Manabu Morita. Journal of Clinical Periodontology
Keywords:animal studies; antioxidants; hydrogen-rich water; oxidative stress; periodontitis
Abstract
Aim
Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis.
Material & Methods
A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water.
The HW (hydrogen concentration; 800–1000 lg/l) was stored in an aluminium bag and placed in a glass vessel twice a day
實驗使用800-1000ppb濃度之含氫水，存至於鋁製袋中施予受測對象
Results
The rats with periodontitis which were treated with pure water showed a time-dependent increase in serum ROS level. Compared with the rats without periodontitis, the periodontitis-induced rats which were given pure water also showed polymorphonuclear leucocyte infiltration and alveolar bone loss at 4 weeks. Hydrogen-rich water intake inhibited an increase in serum ROS level and lowered expression of 8-hydroxydeoxyguanosine and nitrotyrosine in the periodontal tissue at 4 weeks. Such conditions prevented polymorphonuclear leucocyte infiltration and osteoclast differentiation following periodontitis progression. Furthermore, inflammatory signalling pathways, such as mitogen-activated protein kinases, were less activated in periodontal lesions from hydrogen-rich water-treated rats as compared with pure water-treated rats.
Conclusion
Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing gingival oxidative stress.
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