含氫電解水促進三聚氰胺代謝之研究 #韓國研究 #氫水
電解水促進三聚氰胺排泄
本文的假說是功能水，電解水能促進三聚氰胺中毒後的排泄，為證明這個觀點，作者通過建立三聚氰胺中毒動物模型，檢測體重、尿液晶體、結石、生物化學和血液學檢測、腎臟和膀胱組織學檢測等。結果發現，電解水能促進動物的體重增加，同時免疫細胞如淋巴細胞、中性顆粒細胞和單核細胞和脾臟平均重量明顯增加。電解水組尿液中晶體顯著增加，但膀胱結石形成的幾率顯著減少。結石的成分100%為三聚氰胺。這是國際上首次研究關於含氫電解水可以促進三聚氰胺排泄的研究。
The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice
Yang-Suk Yoona, 1, Dong-Heui Kima, 1, Soo-Ki Kimb, Soon-Bong Songa, Young Uhc, Dan Jind, Xu-Feng Qia, Yung-Chien Tenga and Kyu-Jae Leea, e, ,
a Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 220-701, Republic of Korea
b Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 220-701, Republic of Korea
c Department of Laboratory Medicine, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 220-701, Republic of Korea
d Department of Immunology and Pathogenic Biology, College of Medicine, Yanbian University, Yangi, Jilin 133000, China
e Institute for Poverty Alleviation and International Development, Yonsei University Wonju Campus, Wonju, Gangwon 220-710, Republic of Korea
Received 5 February 2011;
accepted 26 April 2011.
Available online 5 May 2011.
Abstract
Our hypothesis is that the intake of functional water, electrolyzed reduced water (ERW) can excrete melamine in body was evoked by melamine-tainted feed (MTF). To address this issue, we investigated the effect of ERW in MTF-mice model by way of body weight gain, incidence of urinary crystals and bladder stone, biochemical and haematological examination, histopathologic finding of kidney and urinary bladder, and the evaluation of bladder stone.
We found that the rate of body weight gain was significantly more increased in MTF + ERW group than MTF + PW group. Accordingly, the number of immunocytes such as leukocyte, neutrophil and monocyte as well as the mean weight of spleen was significantly increased in MTF + ERW group. The incidence of urinary crystals was significantly higher in MTF + ERW group, whereas the incidence of urinary bladder stones was lower in MTF + ERW group (52.4%) than in MTF + PW group (38.1%). Also, urinary crystals were more precipitated in MTF + ERW group than MTF + PW group, and urinary bladder stone consists of 100% melamine. Collectively, our data clearly show that ERW intake is helpful to excrete of melamine in MTF mice model and this is the first report on the melamine excretion and clinically implying the safer fluid remedy for melamine-intoxicated hosts.
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