氫水對順鉑腎臟毒的治療作之研究 #MRI #氫水
氫水對順鉑腎臟毒的治療作用：MRI研究
Investigation of protective effect of hydrogen-rich water against cisplatininduced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging
過去日本學者先後採用一般病理學和生物化學手段，CT等手段證明氫水能治療經典化學治療藥物順鉑腎臟毒。現在他們又採用MRI的方法證明了同樣的作用。
注意他們採用的MRI是的BOLD加權，就是血紅蛋白水準依賴的信號，這個信號過去比較經典的用途是研究腦功能，本質是測定血流的變化。因為當血流下降或升高後，局部靜脈血的血氧含量相對發生改變，這種變化可以用MRI進行顯示。研究通過對腎臟的功能，組織學，動物體重的進行了檢測。全部都支援氫氣對這個疾病的治療作用。
Hydrogen-rich water sealed in a 200-ml aluminum pouch (I’rom Pharmaceutical, Tokyo, Japan) was used. The concentrations of dissolved hydrogen in hydrogen-rich water and standard water were 1.2 ± 0.1 mg/l (mean ± SD) and 0.06 ± 0.01 mg/l, respectively, as measured using a dissolved hydrogen analyzer (DH-35A; DKKTOA, Tokyo, Japan). When feeding, HW from the aluminum pouch was placed into a closed glass vessel. To minimize the loss of hydrogen while feeding, the lid of the glass vessel was equipped with a metal tube containing two ball bearings. The vessels containing the HW given to the rats were freshly prepared twice a da
研究中使用鋁箔袋保存溶氫水，並且低溫至於玻璃密閉容器中，控制最少的氫氣散失。
研究使用1.2 ± 0.1 mg/l =1.2ppm 1200ppb 濃度之溶氫水。
Jpn J Radiol. 2011 Aug;29(7):503-12. Epub 2011 Sep 1.
Investigation of protective effect of hydrogen-rich water against cisplatininduced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging.
Source
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Abstract
PURPOSE:
The aim of this study was to assess the mechanism of the protective effect of hydrogen-rich water (HW) against cisplatin (CP)-induced nephrotoxicity in rats using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).
MATERIALS AND METHODS:
Apparent transverse relaxation time-weighted images (T2*WI) were acquired in 28 rats. The control group (n = 7) had free access to standard water (SW) and no CP injection. The CP group (n = 7) had free access to SW and was given a CP injection on day 0. The CP+HW group (n = 7) had free access to HW and had a CP injection. The HW group (n = 7) had free access to HW and no CP injection. The apparent transverse relaxation rate (R2*) was estimated from T2*WI.
RESULTS:
In the CP+HW group, the R2* value in the medulla normalized by the value of the day 0 was significantly greater than that in the CP group on days 4 and 7. The creatinine and blood urea nitrogen levels in the CP group were significantly higher than those in the control, CP+HW, and HW groups.
CONCLUSION:
BOLD MRI may be useful for demonstrating the change in R2* in CP-induced nephrotoxicity in rats. The changes in the CP+HW group were suspected to be due to a reduction of cytotoxic oxygen radicals.
PMID:21882093 [PubMed - in process]
原文http://blog.sciencenet.cn/home.php?mod=attachment&id=9858
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