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氫水治療化療藥物順鉑引起腎臟毒性之CT研究
氫水治療化療藥物順鉑引起腎臟毒性之CT研究
本文已經發表在《英國放射學雜誌》
去年日本醫科大學太田小組已經發表類似論文。本次文章來自日本大阪大學Kenya Murase小組，不是一個單位，儘管都在東京。
本研究採用了一個新的檢測方法，對動物進行了多層螺旋CT動態增強掃描（dynamic contrast-enhanced CT）檢測腎臟功能，結果發現氫水確實能保護腎臟功能，與血清學檢測結果一致。沒看全文，大概結果如此。
這個雜誌比較一般，發表這個雜誌的唯一理由是採用了這個研究方法，如果採用MRI，那麼就可以走類似路子了。
明顯不足是研究內容實在太少，屬於填縫性論文。不過採用這個“新”技術，仍值得鼓勵提倡。
Hydrogen-rich water sealed in a 200-ml aluminium pouch was kindly provided by I’rom Pharmaceutical (Tokyo, Japan). The process for producing hydrogen-rich water has been described previously [15]. The concentration of dissolved hydrogen was 1.2~0.1 mg l–1 (mean ¡ SD), as measured using a dissolved hydrogen analyser (DH-35A; DKKTOA, Tokyo, Japan).
研究中氫水密封裝入200cc鋁箔袋中，確保氫氣不至於流失，氫水製備應用 此篇論文中的水鎂化合法製備。[15]. Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/ GNL knockout mice
簡單製備純氫水
化學式 Mg + 2H2O → Mg (OH)2 + H2
氫水的製備方法可透過1.電解，2.水與礦石反應、3.高壓灌注，選擇任一方法均可備製水中含氫之氫水，任一方法皆可並無特殊性、惟成本與時間之差異。日本、韓國、中國研究中使用之氫水，均因其實驗設計使用三種方式產生氫水，水中含氫氣即為氫水，檢測方法須應用溶氫檢測儀檢測之、只要水中含氫氣即為醫學研究所定義之氫水。
Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT
A Kitamura, BSc 1 S Kobayashi, BSc 1 T Matsushita, BSc 1 H Fujinawa, PhD 2 and K Murase, PhD 1
1 Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan 2I'rom Pharmaceutical, Tokyo 141-0032, Japan
Correspondence: Dr Kenya Murase, Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
E-mail: murase@sahs.med.osaka-u.ac.jp
Our aim was to assess the protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT (DCE-CT). DCE-CT studies were performed in 30 rats (8 weeks old) on days 0, 2, 4 and 7 using multidetector row CT. The rats were divided into three groups: a control group (n = 6) with free access to standard water and without cisplatin injection, a non-treatment group (n = 12) with free access to standard water and injected with cisplatin (3.6 mg kg–1 body weight) intraperitoneally on day 0 and a treatment group (n = 12) with free access to hydrogen-rich water starting from 7 days before cisplatin injection. The contrast clearance per unit renal volume (K1) was estimated from the DCE-CT data using the Patlak model. The contrast clearance of the entire kidney (K) was obtained by multiplying K1 by the renal volume. The serum creatinine level was also measured on day 7. The K1 and K values normalised by those on day 0 in the treatment group were significantly greater than those in the non-treatment group on days 2, 4 and 7. There were no significant differences in the normalised K value between the treatment and control groups on days 2 and 7. The serum creatinine level in the treatment group was significantly lower than that in the non-treatment group and was not significantly different from that in the control group. This study demonstrated that hydrogen-rich water ameliorates renal dysfunction due to cisplatin-induced nephrotoxicity in rats.
原論文下載:http://goo.gl/QUl1sP
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