氫水能預防因衰老引起的學習能力下降之研究~(原文摘要翻譯)
氫水能預防因衰老引起的腦學習能力下降之研究~
原文摘要翻譯
氫氣因為其抗氧化的能力已經被證實對神經具有保護作用，但是關於衰老對腦部認知部分的損害與底層機制的影響並未著墨，本研究中我們調查了含氫水對於預防早衰動物(SAMP8)在大腦因衰老產生之損害，包括空間認知、綜合老化徵候、學習與記憶力下降...之研究。在實驗中發現，對於衰老小鼠施予氫水30天後，氫水對於因腦老化而造成的空間認知處理能力損害有所幫助，並且能夠提升腦血清素，以及其抗氧化力之提升。此外飲用氫水18周後，與飲用一般水相比，氫水能夠抑制腦海馬體神經的耗損與變異，改善認知能力。我們的研究展示了一個新的契機，每天飲用氫水可以預防因衰老腦部所以起的學習認知能力之下降。
本研究採 水+鎂化合法 製造氫水 以99.9%純鎂製造
化學式 Mg + 2H2O → Mg (OH)2 + H2
氫濃度 0.55-0.65mmol PH值控制在7.7-8.3 微鹼狀態
Drinking hydrogen water ameliorated cognitive impairmentin senescence-accelerated mouse
Abstract
Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects for cognitive impairment in senescence-related brain alterations and the underlying mechanism have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention in spatial memory and age-related alteration of the brain using the senescence-accelerated prone mouse 8 (SAMP8), exhibiting early aging syndromes including declining abilities of learning and memory. In the water maze test, aged SAMP8 mice were impaired in place discrimination and in repeated acquisition tasks. However, treatment with hydrogen water for 30 days resulted in prevention of age-related declines in spatial memory processing abilities, associated with increased brain serotonin levels and elevation of serum antioxidant activity. In addition, drinking of hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, although marked loss of neurons were noted in control aged brain treated with regular water. Our results showed that drinking of hydrogen water on daily basis may present a novel strategy to prevent age-related cognitive disorder.
Key words: hydrogen water, senescence, hippocampus, oxidative stress, cognitive disorder
Hydrogen water
The magnesium stick used to produce hydrogen in the study is a plastic-shelled productconsisting of metallic magnesium (99.9% pure) and natural stones in the poly- propylenecontainers combined with ceramics (Doctor SUISOSUI®, Friendear, Tokyo, Japan). Theproduct is capable of generating hydrogen when placed in drinking water by the followingchemical reaction: Mg + 2H2O → Mg (OH)2 + H2. Hydrogen concentration in thewater bottle was sequentially monitored using a hydrogen needle sensor (DHS-001, ABLE,Tokyo, Japan). Hydrogen concentration was maintained at levels between 0.55 and 0.65mmol and pH was ranged between 7.7 and 8.3.
氫水的製備方法可透過1.電解，2.水與礦石反應、3.高壓灌注，選擇任一方法均可備製水中含氫之氫水，任一方法皆可並無特殊性、惟成本與時間之差異。日本、韓國、中國研究中使用之氫水，均因其實驗設計使用三種方式產生氫水，水中含氫氣即為氫水，檢測方法須應用溶氫檢測儀檢測之、只要水中含氫氣即為醫學研究所定義之氫水。
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